Relationship between peripheral blood IFN-γ secretion level and its prognosis in patients with early stage of acute cerebral hemorrhage
10.3969/j.issn.1671-8348.2018.01.020
- VernacularTitle:急性脑出血患者早期外周血干扰素-γ分泌水平与预后关系的研究
- Author:
Yong XIAO
1
;
Zhengxin XIA
;
Suning ZHANG
;
Yun LING
;
Zhifei ZHANG
;
Hongjuan ZHOU
;
Yuming FANG
Author Information
1. 上海交通大学医学院附属第九人民医院急诊科 201900
- Keywords:
cerebral hemorrhage;
interferon type 1Ⅱ;
prognosis
- From:
Chongqing Medicine
2018;47(1):57-59,62
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the relationship between the peripheral blood IFN-γ secretion level and prognosis in the patients with early stage of acute cerebral hemorrhage.Methods Sixty-six inpatients with acute intracerebral hemorhage in the emergency department of this hospital from July 2015 to August 2016 were selected as the experimental group,and 60 healthy people in the physical examination center served as the blank control group.The peripheral blood mononuclear cells(PBMCs) and plasma were separated.The helper T cells(Th)1/Th2 eytokines(IFN-γ,IL-2,IL-4 and IL-10) were detected by using ELISA.The flow cytometry was used to detect intracellular cytokines;the disease condition change from 1 d of onset to 30 d in the experiment group was analyzed by using NIHSS.The relationship between the cytokines and prognosis on 30 d evaluated by NIHSS score was analyzed.Results The peripheral blood IFN-γ level had statistically significant difference between the two groups(P＜0.05),while the levels of IL-2,IL-4 and IL-10 had no statistical difference(P＞0.05).The peripheral blood IFN-γ secretion level during early stage in the experimental group was positively correlated with the prognosis(P＜0.05).Conclusion The increase of peripheral blood IFN-γ during early stage is correlated with the poor prognosis in the patients with acute intracerebral hemorrhage.
