Research on influencing of CYP2C18 gene polymorphism on warfarin dose after valve replacement surgery
10.3969/j.issn.1671-8348.2017.35.024
- VernacularTitle:CYP2C18基因多态性对瓣膜置换术后服用华法林剂量的影响研究
- Author:
Yinqiang LIU
1
;
Peigang OUYANG
;
Kang LUO
;
Xueyu ZHANG
;
Guimin ZHANG
Author Information
1. 昆明医科大学第一附属医院心脏大血管外科 650032
- Keywords:
polymorphism,single nucleotide;
warfarin;
valve replacement surgery;
CYP2C18
- From:
Chongqing Medicine
2017;46(35):4974-4976
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the CYP2C18,VKORC1 and CYP2C9 genotype distribution situation and the correlation between their polymorphism with warfarin stable dose.Methods A total of 176 Yungui plateau Han patients with continuously warfarin anticoagulation therapy after valve replacement in this hospital from January 2011 to January 2014 served as the research subjects.The venous blood was collected for detecting genotypes at various loci.The genotype and allele frequency distribution were analyzed,and the correlation between the gene polymorphism with warfarin stable dose was analyzed.Results The genotypes and allele frequencies at various loci conformed to the Hardy-Winberg genetic balance (P＞0.05).The polymorphisms of CYP2C18 (rs7896133),VKORC1 (rs9923231),CYP2C9(rs1057910) and CYP2C9(rs4086116) gene loci were correlated with warfarin stable dose (P＞0.05).Conclusion The gene polymorphism of CYP2C18(rs7896133),VKORC1 (rs9923231),CYP2C9(rs1057910) and CYP2C9(rs4086116) in Yungui plateau H an patients may be the influence factors which contribute to warfarin stable dose personalized difference.
