Study on correlation between serum sFas and sLOX-1 with occurrence and development of acute coronary syndrome
10.3969/j.issn.1671-8348.2017.35.023
- VernacularTitle:血清sFas和sLOX-1与急性冠状动脉综合征发生及发展的相关性研究
- Author:
Yanqing HU
1
;
Jianqun MA
;
Ziwen SUN
;
Zhenzhen FENG
;
Huipu XU
Author Information
1. 济南大学山东省医学科学院医学与生命科学学院
- Keywords:
acute coronary syndrome;
soluble Fas;
soluble lectin-like oxidized low-density lipoprotein receptor-1;
apoptosis;
inflammatory response
- From:
Chongqing Medicine
2017;46(35):4971-4973
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum sFas and sLOX-1 with occurrence and development of acute coronary syndrome (ACS).Methods A total of 52 patients definitely diagnosed ACS (ACS group) by coronary artery angiography (CAG) were enrolled,including 23 cases of unstable angina (UA group) and 29 cases of acute myocardial infarction (AMI group),and contemporaneous 58 cases of non-coronary arterial stenosis confirmed by CAG were selected as the control group (NC group).The serum levels of sFas and sLOX-1 were measured by enzyme linked immunosorbent assay.Results Compared with the NC group,the serum levels of sFas and sLOX-1 in the ACS group were increased,the serum levels of sFas and sLOX-1 in the AMI group and UA group were higher than those in the NC group,moreover which in the AMI group were higher than those in the UA group (P＜0.01).The serum sFas level in the ACS group was positively correlated with the sLOX-1 level (r=0.825,P=0.001),but both had no obvious correlation with the serum levels of CK-MB and cTnⅠ (P＞0.05).Conclusion High levels of serum sFas and sLOX-1 may be the risk factors of ACS.
