Changes of microparticle levels before and after daunorubicin-based chemotherapy in patients with acute leukemia
10.3760/cma.j.issn.1009-9921.2018.10.004
- VernacularTitle:急性白血病患者柔红霉素为主方案化疗前后微粒水平的变化
- Author:
Jing CUI
1
;
Tienan ZHU
;
Yongqiang ZHAO
Author Information
1. 福建医科大学附属第一医院化疗科
- Keywords:
Leukemia;
acute;
Antineoplastic combined chemotherapy protocols;
Daunorubicin;
Endothelial particles;
Tissue factor-bearing microparticles
- From:
Journal of Leukemia & Lymphoma
2018;27(10):591-594
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the serum levels of endothelial microparticles (EMP) and tissue factor-bearing microparticles (TF+MP) in patients with acute leukemia before and after daunorubicin-based chemotherapy. Methods From July 2012 to February 2013, 15 patients with newly diagnosed acute leukemia in Peking Union Medical College Hospital received DA (daunorubicin + cytarabine) regimen or VDCLP (vincristine + daunorubicin + cyclophosphamide + L-asparaginase + prednisone) regimen chemotherapy. There were 8 males and 7 females, and the median age of patients was 44 years old. Eleven patients were acute myeloid leukemia (M01 case, M11 case, M29 cases), and 4 were acute lymphocytic leukemia. The peripheral blood samples were taken before induction chemotherapy and after 3 days of daunorubicin. Levels of EMP and TF+MP were assessed using flow cytometry. Results The serum EMP and TF+MP levels were significantly higher after 3-day daunorubicin infusions than those before induction chemotherapy (28.94/μl vs. 10.74/μl, P= 0.001; 64.24/μl vs. 43.80/μl, P= 0.02). Conclusion Daunorubicin-based chemotherapy may cause increased numbers of EMP and TF+MP in patients with acute leukemia.
