Progress of circulating cell-free DNA in B-cell neoplasms

VernacularTitle:循环细胞游离DNA在B细胞肿瘤中的研究进展
Author: Feilong ZHANG ¹ ; Aijun LIU
Author Information

1. 100020,首都医科大学附属北京朝阳医院血液科
Keywords: B-cell neoplasms; Circulating cell-free DNA; Liquid biopsy
From: Journal of Leukemia & Lymphoma 2018;27(9):567-570
CountryChina
Language:Chinese
Abstract: Circulating cell-free DNA (cfDNA) is a kind of free DNA in circulating blood, including circulating tumor DNA (ctDNA) deriving from tumor cells and DNA deriving from normal tissue cells. CtDNA is a specific tumor DNA in cfDNA. CfDNA could reflect the status of tumor to a certain extent, which plays an important role in tumor diagnosis, disease monitoring, treatment evaluation, prognosis and recurrence judgement, and has a potential clinical value as a simple, effective and noninvasive "liquid biopsy"technology. As a new concept, the number of cfDNA analysis in B-cell tumors is increasing, such as the relationship between tumor-specific gene mutations, methylation changes, minimal residual disease (MRD) and prognosis, recurrence, monitoring of treatment effects, targeted therapy by using cfDNA sequencing technology.