Progress of chimeric antigen receptor modified natural killer cells immunotherapy in hematological neoplasms

VernacularTitle:嵌合抗原受体修饰的NK细胞免疫治疗在血液肿瘤中的研究进展
Author: Xuehang FU ¹ ; Min WANG
Author Information

1. 中国医学科学院北京协和医学院血液学研究所血液病医院实验血液学国家重点实验室
Keywords: Hematologic neoplasms; Chimeric antigen receptor; Killer cells,natural
From: Journal of Leukemia & Lymphoma 2018;27(9):563-566
CountryChina
Language:Chinese
Abstract: Chimeric antigen receptor modified T (CAR-T) cells have been a kind of promising immunotherapeutic strategy for the treatment of malignances, which could target the specific antigen and exert a specific cytotoxic effect by gene modification of T cells. There has been a great stride in B lymphocytic leukemia along with CAR-T therapy. As the essential effector cells of the innate immune system, natural killer (NK) cells play a critical role in host immunity against cancer and have a wide application prospect in the tumor immunotherapy. The potential of CAR modification in NK cells has also attracted much attention. A lot of remarkable results have been obtained in vitro experiments and animal model of CAR-NK targeting hematologic neoplasms. This paper reviews the progress of CAR-NK immunotherapy in hematological malignancies.