Causes of bone marrow dry pumping in patients with hypocytosis or hematocytosis
10.3760/cma.j.issn.1009-9921.2018.09.008
- VernacularTitle:血细胞减少或增多患者骨髓穿刺干抽的相关原因分析
- Author:
Yajun JIANG
1
;
Wanchuan ZHUANG
;
Guihua ZHU
;
Yao HE
;
Xingxing CHAI
;
Xiaoyun YANG
;
Fanjing MENG
Author Information
1. 222006,江苏省连云港市第二人民医院血液内科
- Keywords:
Hypocytosis;
Hematocytosis;
Myelofibrosis;
Biopsy,needle
- From:
Journal of Leukemia & Lymphoma
2018;27(9):539-542
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze some related causes of hypocytosis or hematocytosis with bone marrow dry pumping. Methods Bone marrow histology, reticular fiber staining and selective immunohistochemical staining were performed in 34 bone marrow dry pumping patients with hypocytosis or hematocytosis in the Second People's Hospital of Lianyungang from January 2012 to August 2017. Results All the patients showed dizziness, fatigue, splenomegaly, night sweats and bleeding, including primary myelofibrosis (17 cases, 50.0 %), chronic myelocytic leukemia (4 cases, 11.8 %), acute myelocytic leukemia (2 cases, 5.9 %), acute lymphoblastic leukemia (1 case, 2.9 %), myelodysplastic syndrome (2 cases, 5.9 %), multiple myeloma (2 cases, 5.9 %), non-Hodgkin lymphoma with bone marrow infiltration (2 cases, 5.9 %), polycythemia vera (1 case, 2.9 %) and bone marrow metastatic tumor (3 cases, 8.8 %). The bone marrow proliferative degree in primary myelofibrosis group was mainly "grade Ⅱ" to "grade Ⅳ", and the non primary myelofibrosis group was mainly "grade Ⅲ" to "grade Ⅴ", and the differences of proliferative degree component between them were statically significant (χ2＝ 12.900, P＝ 0.004). The fibrosis level in primary myelofibrosis group was mainly "grade 2" to "grade 3", and the non primary myelofibrosis group was mainly "grade 1" to "grade 2", and the differences of myelofibrosis degree component between them were also statistically significant (χ2＝ 12.692, P＝ 0.003). Conclusions Hematological malignancies, especially primary myelofibrosis, are the common causes of bone marrow "dry pumping". Bone marrow histology, reticular fiber staining and selective immunohistochemical staining are of great significance in the etiological diagnosis.
