Acute myeloid leukemia secondary to angioimmunoblastic T-cell lymphoma: report of three cases and review of literature
10.3760/cma.j.issn.1009-9921.2018.03.009
- VernacularTitle:血管免疫母细胞性T细胞淋巴瘤继发急性髓系白血病三例并文献复习
- Author:
Yufeng SHANG
1
;
Xiaorui FU
;
Lei ZHANG
;
Feifei NAN
;
Mingzhi ZHANG
;
Xinhua WANG
Author Information
1. 450002,郑州大学第一附属医院肿瘤科
- Keywords:
Angioimmunoblastic T-cell lymphoma;
Leukemia;
myeloid;
acute;
Secondary neoplasm;
Pathogenesis;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2018;27(3):164-167
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics, pathogenesis, diagnosis, treatment and prognosis of acute myeloid leukemia secondary to angioimmunoblastic T-cell lymphoma. Methods The clinical data of 3 patients with acute myeloid leukemia secondary to angioimmunoblastic T-cell lymphoma including immunohistochemistry and flow cytometer analysis were analyzed retrospectively, then the literature was reviewed. Results All the 3 patients were elderly men and the initial diagnosis was angioimmunoblastic T-cell lymphoma. The 3 cases developed secondary acute myeloid leukemia in 8 months, 14 months and 34 months after treating primary neoplasms respectively. After diagnosed acute myeloid leukemia, one case died 10 months later without treatment, one case died 13 months later despite aggressive treatment and one case lost follow-up. Conclusion Angioimmunoblastic T-cell lymphoma has risk to developing acute myeloid leukemia, and there is a poor survival and the pathogenesis is unclear.
