Genetic characteristics of myelodysplastic syndromes
10.3760/cma.j.issn.1009-9921.2018.03.003
- VernacularTitle:骨髓增生异常综合征的基因和遗传学特征
- Author:
Xudong TANG
1
;
Lu ZHANG
;
Xiupeng YANG
;
Yufeng TANG
;
Dexiu WANG
Author Information
1. 中国中医科学院西苑医院血液科
- Keywords:
Myelodysplastic syndromes;
Genetics;
Diagnosis;
Therapy
- From:
Journal of Leukemia & Lymphoma
2018;27(3):139-142
- CountryChina
- Language:Chinese
-
Abstract:
Myelodysplastic syndromes (MDS) is a clinical heterogeneous disease characterized by impaired hematopoietic function and morphologic abnormalities of the bone marrow. Genomic studies show that MDS is usually driven by a series of multistep somatic cell genetic processes that affect the core genome. By definition, reproducible MDS drives mutations leading to cloning advantage. In addition, exposure factors, such as cytotoxic chemotherapy or genetic propensity of the reproductive system, could affect the pathogenesis and clinical outcomes of the disease. Combined with the reports in the 59th American Society of Hematology (ASH) Annual Meeting, the article introduces the genetic characteristics of MDS, in order to improve the diagnosis of MDS and the understanding of the pathogenesis of treatment-related MDS as well as the genetic tendency of MDS in the reproductive system.
