Influence of implants prepared by selective laser melting on early bone healing.
- Author:
Jing Yin LIU
1
;
Fei CHEN
2
;
Yan Jun GE
2
;
Ling WEI
2
;
Shao Xia PAN
2
;
Hai Lan FENG
2
Author Information
1. Department of Prosthodontics, First Clinical Division, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100034, China.
2. Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Dental Implantation, Endosseous;
Dental Implants;
Dental Prosthesis Design;
Dogs;
Male;
Mandible;
Osseointegration;
Surface Properties;
Titanium
- From:
Journal of Peking University(Health Sciences)
2018;50(1):117-122
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the influence of the rough surface of dental implants prepared by selective laser melting (SLM) on early bone healing around titanium implants.
METHODS:A total of sixteen titanium implants were involved in our research, of which eight implants were prepared by SLM (TIXOS Cylindrical, Leader-Novaxa, Milan, Italy; 3.3 mm×10 mm, internal hex) and the other eight were sandblasted, large-grit and acid-etched (SLA) implants (IMPLUS Cylindrical, Leader-Novaxa, Milan, Italy; 3.3 mm×10 mm, internal hex). All of the dental implants were inserted into the healed extraction sockets of the mandible of two adult male Beagle dogs. Half of the dental implants were designed to be healed beneath the mucosa and the other half were intended to be healed transgingivally and were immediately loaded by acrylic resin bridge restoration. Three types of tetracycline fluorescent labels, namely calcein blue, alizarin complexone and calcein, were administered into the veins of the Beagle dogs 2, 4, and 8 weeks after implant placement respectively for fluorescent evaluation of newly formed bone peri-implant. Both Beagle dogs were euthanized 12 weeks after implant insertion and the mandible block specimens containing the titanium implants and surrounding bone and soft tissue of each dog were carefully sectioned and dissected. A total of 16 hard tissue slices were obtained and stained with toluidine blue for microscopic examination and histomorphometric measurements. Histological observation was made for each slice under light microscope and laser scanning confocal microscope (LSCM). Comparison on new bone formation around titanium implants of each group was made and mineral apposition rate (MAR) was calculated for each group.
RESULTS:Dental implants prepared by selective laser melting had achieved satisfying osseointegration to surrounding bone tissue after the healing period of 12 weeks. Newly formed bone tissue was observed creeping on the highly porous surface of the SLM implant and growing into the pores of surface structure. Higher MAR values were shown for SLM implants compared with SLA implants (P<0.01).
CONCLUSION:Dental implants prepared by selective laser melting could promote early bone healing and improve mineral apposition rate.
