Expression and clinical significance of ERp29 in colorectal cancer

VernacularTitle:ERp29在结直肠癌中的表达及其临床意义
Author: Zhuli TAN ¹ ; Hai YU ; Xiping DING
Author Information

1. 安徽医科大学附属省立医院消化内科
Keywords: colorectal cancer; ERp29; endoplasmic reticulum; metastasis
From: Acta Universitatis Medicinalis Anhui 2018;53(1):123-126
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression and clinical significance of endoplasmic reticulum protein 29(ERp29) in colorectal cancer. Methods Paraffin-embedded sections from 62 cases of colorectal cancer tissues were obtained and used for immunohistochemical staining of ERp29. The clinical and pathological data of various levels of ERp29 in patients with colorectal cancer were analyzed to determine if there was a significant difference. Results The expression of ERp29 in 62 cases of colorectal cancer tissues, 24(38. 7％ ) cases were positive and 38(61. 3％ )cases were negative. The expression of ERp29 in 62 cases of adjacent tissues, 58 (93. 5％ ) cases were positive and 4(6. 5％ ) cases were negative. There was a significant difference in TNM classification and lymph node metastasis between ERp29 positive group and ERp29 negative group (P ＜ 0. 05 ). Conclusion Colorectal cancer tissues have significantly lower levels of ERp29 than adjacent tissues. ERp29 may be helpful to evaluate the metastatic proclivity and prognosis of colorectal cancer.