Association between transcription KCNQ1 rs2237892 polymorphism and development of type 2 diabetes in Hefei

VernacularTitle:KCNQ1基因rs2237892多态性与合肥地区汉族人2型糖尿病的相关性
Author: Jianfeng CHEN ¹ ; Tianrong PAN
Author Information

1. 安徽医科大学第二附属医院内分泌科
Keywords: type 2 diabetes mellitus; KCNQ1 rs2237892; polymorphism
From: Acta Universitatis Medicinalis Anhui 2018;53(1):110-113
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship of KCNQ1 rs2237892 polymorphism with type 2 diabetes mellitus(T2DM) in Hefei. Methods A total of 104 healthy individual(control group) and 84 patients with T2DM(T2DM group) were enrolled. The rs2237892 polymorphism KCNQ1 gene was detected by PCR-RFLP. The genetype, allele frequency, related clinical and biochemical data were compared between the two groups. Results There were no significant differences in alleles or genotype frequencies of KCNQ1 rs2237892 gene among control group and T2DM group. The result of Logistic regression analysis showed that the risk of T2DM in the subjects with CT genetype of rs2237892 was 1. 44 times of those with CC genotype(OR =1.44, 95％ CI: 1. 06 ～ 1. 95, P=0. 02). Conclusion KCNQ1 rs2237892 gene may be the susceptibility gene of T2DM in Hefei.