Anti-inflammatory and Antimicrobial Effects of Anthocyanin Extracted from Black Soybean on Chronic Bacterial Prostatitis Rat Model.

Byung Il Yoon; Woong Jin Bae; Yong Sun Choi; Su Jin Kim; U Syn HA; Sung-hoo Hong; Dong Wan Sohn; Sae Woong Kim

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Anti-inflammatory and Antimicrobial Effects of Anthocyanin Extracted from Black Soybean on Chronic Bacterial Prostatitis Rat Model.

Author: Byung Il YOON ¹ ; Woong Jin BAE ² ; Yong Sun CHOI ² ; Su Jin KIM ² ; U Syn HA ² ; Sung-Hoo HONG ² ; Dong Wan SOHN ² ; Sae Woong KIM ³
Author Information

1. Department of Urology, International St Mary's Hospital, The Catholic Kwandong University of Korea, Incheon, Republic of Korea.
2. Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
3. Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. ksw1227@catholic.ac.kr.
Publication Type:Journal Article
Keywords: anthocyanins; anti-bacterial agents; prostatitis
MeSH: Acinar Cells; drug effects; pathology; Animals; Anthocyanins; isolation & purification; pharmacology; therapeutic use; Anti-Infective Agents; pharmacology; therapeutic use; Anti-Inflammatory Agents; pharmacology; therapeutic use; Chronic Disease; Disease Models, Animal; Escherichia coli Infections; drug therapy; urine; Fibrosis; Inflammation; pathology; Male; Plant Extracts; pharmacology; therapeutic use; Prostate; drug effects; microbiology; pathology; Prostatitis; drug therapy; microbiology; urine; Rats, Sprague-Dawley; Severity of Illness Index; Soybeans; chemistry; Urine; microbiology
From: Chinese journal of integrative medicine 2018;24(8):621-626
CountryChina
Language:English
Abstract:
OBJECTIVETo investigated the anti-inflammatory and antimicrobial effects of anthocyanins extracted from black soybean on the chronic bacterial prostatitis (CBP) rat model.
METHODSThe Sprague-Dawley rats were divided into 4 groups, including control, ciprofloxacin, anthocyanins and anthocyanins with ciprofloxacin groups (n=8 in each group). Then, drip infusion of bacterial suspension (Escherichia coli Z17 O:K:H) into Sprague-Dawley rats was conducted to induce CBP. In 4 weeks, results of prostate tissue, urine culture, and histological analysis on the prostate were analyzed for each group.
RESULTSThe use of ciprofloxacin, anthocyanins, and anthocyanins with ciprofloxacin showed statistically significant decreases in bacterial growth and improvements in the reduction of prostatic inflammation compared with the control group (P<0.05). The anthocyanins with ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the ciprofloxacin group (P<0.05).
CONCLUSIONSThese results suggest that anthocyanins may have anti-inflammatory and antimicrobial effects, as well as a synergistic effect with ciprofloxacin. Therefore, we suggest that the combination of anthocyanins and ciprofloxacin may be effective in treating CBP to obtain a higher rate of treatment success.