Research Progress of Histone Modification in B Cell Lymphoma Pathogenesis-Review.
10.7534/j.issn.1009-2137.2018.02.052
- Author:
Jiao ZHANG
1
;
Yun PAN
2
;
Yan LI
3
Author Information
1. Department of Pathology, Basic Medical College of Dali University,Dali 671000, Yunnan Province, China.
2. Department of Pathology, The Affiliated Hospital of Dali University, Dali 671000, Yunnan Province, China.
3. Department of Pathology, Basic Medical College of Dali University,Dali 671000, Yunnan Province, China. E-mail: bigbigsmile04@aliyun.com.
- Publication Type:Journal Article
- MeSH:
DNA Methylation;
Epigenesis, Genetic;
Histone Code;
Histones;
Humans;
Lymphoma, B-Cell
- From:
Journal of Experimental Hematology
2018;26(2):615-620
- CountryChina
- Language:Chinese
-
Abstract:
It has been increasingly recognized that the pathogenesis of B-cell lymphoma closely relates to the epigenetic disregulations. Epigenetics is a subdiscipline, which means heritable changes in gene expressions without alterations in the DNA sequence, and the DNA methylation, histone modification and miRNA maily were involved. Histone modification is the most important epigenetic modification, the researches showed that the aberrant histone modification is the important pathogenesis in B-cell lymphoma, especially the aberrant histone methylation and acetylation. In the meantime, the tumor can be treated by changing the epigenetic modification, which become a research hotpoint. This review summarizes the pathogenesis of B cell lymphoma and discusses the epigenetic treatment of B cell lymphoma mainly in terms of histone modification regulation for B cell development in the germinal center and mutation of histone madification enzymes.
