An updated overview on the development of new photosensitizers for anticancer photodynamic therapy.
10.1016/j.apsb.2017.09.003
- Author:
Juan ZHANG
1
;
Chengshi JIANG
1
;
João Paulo Figueiró LONGO
2
;
Ricardo Bentes AZEVEDO
2
;
Hua ZHANG
1
;
Luis Alexandre MUEHLMANN
2
Author Information
1. School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
2. Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil.
- Publication Type:Journal Article
- Keywords:
Anti-cancer;
BODIPY;
Oncology;
Photochemical reactions;
Photodynamic therapy;
Photosensitizers
- From:
Acta Pharmaceutica Sinica B
2018;8(2):137-146
- CountryChina
- Language:English
-
Abstract:
Photodynamic therapy (PDT), based on the photoactivation of photosensitizers (PSs), has become a well-studied therapy for cancer. Photofrin, belonging to the first generation of PS, is still widely used for the treatment of different kinds of cancers; however, it has several drawbacks that significantly limit its general clinical use. Consequently, there has been extensive research on the design of PS molecules with optimized pharmaceutical properties, with aiming of overcoming the disadvantages of traditional PS, such as poor chemical purity, long half-life, excessive accumulation into the skin, and low attenuation coefficients. The rational design of novel PS with desirable properties has attracted considerable research in the pharmaceutical field. This review presents an overview on the classical photosensitizers and the most significant recent advances in the development of PS with regard to their potential application in oncology.
