The combined therapeutic effects of iodine-labeled multifunctional copper sulfide-loaded microspheres in treating breast cancer.
10.1016/j.apsb.2018.04.001
- Author:
Qiufang LIU
1
;
Yuyi QIAN
2
;
Panli LI
1
;
Sihang ZHANG
2
;
Zerong WANG
3
;
Jianjun LIU
1
;
Xiaoguang SUN
1
;
Michael FULHAM
4
;
Dagan FENG
4
;
Zhigang CHEN
5
;
Shaoli SONG
1
;
Wei LU
2
;
Gang HUANG
1
Author Information
1. Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
2. Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education & State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 201203, China.
3. Shanghai Gezhi Middle School, Shanghai 200001, China.
4. SJTU-USYD Joint Research Alliance for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
5. Centre for Future Materials, University of Southern Queensland, Springfield QLD 4300, Australia.
- Publication Type:Journal Article
- Keywords:
Combination therapy;
Microspheres;
Photoacoustic imaging;
Single photon emission computed tomography/computed tomography (SPECT/CT);
Theranostics
- From:
Acta Pharmaceutica Sinica B
2018;8(3):371-380
- CountryChina
- Language:English
-
Abstract:
Compared to conventional cancer treatment, combination therapy based on well-designed nanoscale platforms may offer an opportunity to eliminate tumors and reduce recurrence and metastasis. In this study, we prepared multifunctional microspheres loading I-labeled hollow copper sulfide nanoparticles and paclitaxel (I-HCuSNPs-MS-PTX) for imaging and therapeutics of W256/B breast tumors in rats. F-fluordeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) imaging detected that the expansion of the tumor volume was delayed (<0.05) following intra-tumoral (i.t.) injection with I-HCuSNPs-MS-PTX plus near-infrared (NIR) irradiation. The immunohistochemical analysis further confirmed the anti-tumor effect. The single photon emission computed tomography (SPECT)/photoacoustic imaging mediated by I-HCuSNPs-MS-PTX demonstrated that microspheres were mainly distributed in the tumors with a relatively low distribution in other organs. Our results revealed that I-HCuSNPs-MS-PTX offered combined photothermal, chemo- and radio-therapies, eliminating tumors at a relatively low dose, as well as allowing SPECT/CT and photoacoustic imaging monitoring of distribution of the injected agents non-invasively. The copper sulfide-loaded microspheres, I-HCuSNPs-MS-PTX, can serve as a versatile theranostic agent in an orthotopic breast cancer model.
