C-Diterpenoid alkaloid arabinosides from an aqueous extract of the lateral root of and their analgesic activities.
10.1016/j.apsb.2018.03.009
- Author:
Qinglan GUO
1
;
Huan XIA
1
;
Xianhua MENG
1
;
Gaona SHI
1
;
Chengbo XU
1
;
Chenggen ZHU
1
;
Tiantai ZHANG
1
;
Jiangong SHI
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
Aconicarmichosides E−L;
Aconitum carmichaelii;
Analgesic effect;
Arabinoside;
C19-diterpenoid alkaloid;
Ranunculaceae;
Structure–activity relationship
- From:
Acta Pharmaceutica Sinica B
2018;8(3):409-419
- CountryChina
- Language:English
-
Abstract:
Eight new C-diterpenoid alkaloid arabinosides, named aconicarmichosides E-L (-), were isolated from an aqueous extract of the lateral roots of (Fu Zi). Their structures were determined by spectroscopic and chemical methods including 2D NMR experiments and acid hydrolysis. Compounds -, together with the previously reported four neoline 14--arabinosides from the same plant, represent the only examples of glycosidic diterpenoid alkaloids so far. At a dose of 1.0 mg/kg (i.p.), as compared with the black control, compounds , , and - exhibited analgesic effects with >65.6% inhibitions against acetic acid-induced writhing of mice. Structure-activity relationship was also discussed.
