Limonoids from seeds of A. Juss. and their cytotoxic activity.
10.1016/j.apsb.2017.12.009
- Author:
Jian CHEN
1
;
Xiaona FAN
2
;
Jianhua ZHU
1
;
Liyan SONG
1
;
Zhiwei LI
1
;
Fei LIN
3
;
Rongmin YU
1
;
Hanhong XU
3
;
Jiachen ZI
1
Author Information
1. Biotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, China.
2. School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.
3. State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou 510642, China.
- Publication Type:Journal Article
- Keywords:
Azadirachta indica;
Cytotoxic activity;
Limonoid;
Nortriterpenoid;
Spectroscopy
- From:
Acta Pharmaceutica Sinica B
2018;8(4):639-644
- CountryChina
- Language:English
-
Abstract:
Four new limonoid-type nortriterpenoids, 1-detigloyl-1--methacryloylsalannin (), 28-deoxo-2,3-dihydronimbolide (), 12-acetoxy-3--acetyl-7--tigloylvilasinin () and 12-acetoxy-3--acetyl-7--methacryloylvilasinin (), along with five known ones, were isolated from seeds of A. Juss. Their structures were elucidated by various spectroscopic methods, including UV, IR, MS, NMR, X-ray crystallography, quantum chemical calculation, as well as by comparison of their spectroscopic data with those reported. In the cytotoxic assay, showed inhibitory activity against human breast cancer MDA-MB-231 cell line with IC value of 7.68±1.74 μmol/L, and inhibited growth of human cervical cancer Hela cell line, melanoma A375 cell line and promyelocytic leukemia HL-60 cell line, with IC 12.00±2.08, 17.44±2.11, and 13.95±5.74 μmol/L, respectively.
