Helioscopianoids A-Q, bioactive jatrophane diterpenoid esters from .
10.1016/j.apsb.2018.03.011
- Author:
Zhenpeng MAI
1
;
Gang NI
1
;
Yanfei LIU
1
;
Zhao ZHANG
1
;
Li LI
1
;
Naihong CHEN
1
;
Dequan YU
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
Euphorbia helioscopia;
Helioscopianoids A–Q;
Jatrophanes;
Neuroprotective effect;
P-glycoprotein (ABCB1) inhibitory activity
- From:
Acta Pharmaceutica Sinica B
2018;8(5):805-817
- CountryChina
- Language:English
-
Abstract:
The EtOH extracts of the whole plants of afforded 17 new jatrophane diterpenoid esters, helioscopianoids A-Q (-), along with eight known compounds (-). Their structures were elucidated by extensive spectroscopic methods and Mo(OAc)-induced ECD analysis, and the structures of compounds , , and were confirmed by X-ray crystallography. Compounds - were evaluated for inhibitory effects on P-glycoprotein (P-gp) in an adriamycin (ADM)-resistant human breast adenocarcinoma cell line (MCF-7/ADR) and neuroprotective effects against serum deprivation-induced and rotenone-induced PC12 cell damage. Compounds and increased the accumulation of ADM in MCF-7/ADR cells by approximately 3-fold at a concentration of 20 μmol/L. Compound could attenuate rotenone-induced PC12 cell damage, and compounds , , and showed neuroprotective activities against serum deprivation-induced PC12 cell damage.
