Bioactive thionic compounds and aromatic glycosides from .
10.1016/j.apsb.2018.04.002
- Author:
Xu ZHANG
1
;
Bing HAN
1
;
Ziming FENG
1
;
Jianshuang JIANG
1
;
Yanan YANG
1
;
Peicheng ZHANG
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory;
Aromatic glycosides;
Ligusticum chuanxiong Hort.;
Natural products;
Thionic compounds
- From:
Acta Pharmaceutica Sinica B
2018;8(5):818-824
- CountryChina
- Language:English
-
Abstract:
Three new thionic compounds, ()-2-(2-carboxyl-2-hydroxyethylthio)-ferulic acid (), ()-2-methoxy-4-(3-(methylsulfonyl)prop-1-en-1-yl)phenol (), and thiosenkyunolide C (), together with two new aromatic glycosides ( and ) were isolated from the rhizome of Hort. Two known compounds ( and ) were also obtained. Their structures were elucidated based on extensive spectroscopic data (UV, IR, 1D and 2D NMR, and HR-ESI-MS). Furthermore the absolute configurations were established by comparison of their calculated and experimental circular dichroism spectra and by a dimolybdenum tetraacetate [Mo(AcO)]-induced circular dichroism procedure. All compounds were evaluated against lipopolysaccharide (LPS)-induced NO production in BV2 cells, and compounds and showed strong inhibitory activities with IC values of 2.03 and 3.09 µmol/L, respectively (positive control curcumin, IC = 6.17 µmol/L). In addition, compound showed weak proteintyrosine phosphatase-1B (PTP1B) inhibitory activity.
