IgG4-Related Tubulointerstitial Nephritis Accompanied by Henoch-Schonlein Purpura.
- Author:
Hyun YANG
1
;
Soo Kyoung CHOI
;
Bokyoung KIM
;
Ji Yeon YOO
;
Eun Sil KOH
;
Yoon Sik CHANG
;
Sungjin CHUNG
Author Information
1. Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. sungjin.chung@outlook.com
- Publication Type:Case Report
- Keywords:
Immunoglobulin G4;
Nephritis, Interstitial;
Henoch-Schonlein purpura
- MeSH:
Biopsy;
Creatinine;
Humans;
Immunoglobulin A;
Immunoglobulin G;
Kidney;
Leg;
Middle Aged;
Nephritis, Interstitial*;
Plasma Cells;
Purpura;
Purpura, Schoenlein-Henoch*;
Skin;
Vasculitis
- From:Korean Journal of Medicine
2014;87(1):96-100
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Tubulointerstitial nephritis is one of the common manifestations of immunoglobulin G (IgG)4-related disease; however, among all cases of tubulointerstitial nephritis undergoing renal biopsies, IgG4-related tubulointerstitial nephritis seems to be relatively rare because of its trivial urinary findings. A previously healthy 54-year-old man was referred to our clinic with a 4-week history of lower leg purpura and renal dysfunction. A kidney biopsy was planned because of bilateral renomegaly, by imaging studies, and elevated serum creatinine levels. Pathological findings in the kidney showed prominent infiltration of IgG4-postive plasma cells in the tubulointerstitium, but not the glumeruli. A skin biopsy revealed leukocytoclastic vasculitis, accompanied by deposition of IgA and C3 in the vascular wall, indicating Henoch-Schonlein purpura (HSP). Although cases of combined IgG4-related disease and microvasculitis, including HSP, are extremely rare, the possibility of an association between two diseases deserves attention.
