A new fatty acid methyl ester from Fissistigma oldhamii inhibiting proliferation of synoviocytes.
10.19540/j.cnki.cjcmm.20180125.006
- Author:
Xue-Ming ZHOU
1
;
Bin ZHANG
1
;
Yu-Qin ZHANG
2
;
Guang-Ying CHEN
1
;
Wei XU
2
;
Jin CAI
1
;
Shan LIAO
1
Author Information
1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
2. College of Pharmacy, Fujian University of Traditional Chinese Medicine College of Pharmacy, Fuzhoun 350122, China.
- Publication Type:Journal Article
- Keywords:
Annonaceae;
Fissistigma oldhamii;
fatty acid methyl ester;
synoviocytes
- From:
China Journal of Chinese Materia Medica
2018;43(9):1754-1757
- CountryChina
- Language:Chinese
-
Abstract:
A new fatty acid methyl ester (1) was isolated from an EtOH extract of Fissistigma oldhamii. It structures was elucidated by a combination of HR-ESI-MS, 1D NMR, 2D NMR, UV, and IR spectroscopic data. The inhibitory effect of compound 1 on the proliferation of primary synovial cells was evaluated. As a result, it showed inhibitory effect on the proliferation of synoviocytes, with IC₅₀ value of 38.6 μmol·L⁻¹.
