Research and application of quercetin-loaded nano drug delivery system.
10.19540/j.cnki.cjcmm.20180312.002
- Author:
Shao-Jing LI
1
;
Ying-Fen LIAO
1
;
Qing DU
1
Author Information
1. Hebei Medical University, Shijiangzhuang 050017, China.
- Publication Type:Journal Article
- Keywords:
bioavailability;
drug release;
nano drug delivery system;
quercetin;
solubility;
stability;
therapeutic effect
- From:
China Journal of Chinese Materia Medica
2018;43(10):1978-1984
- CountryChina
- Language:Chinese
-
Abstract:
Quercetin has a variety of biological activities and pharmacological effects, but its clinical application is limited due to its low water solubility, low bioavailability and poor chemical stability. In order to overcome the above shortcomings of quercetin and achieve better clinical efficacy, many new drug delivery systems have been studied and developed in recent years, of which nano drug delivery system has become a research hotspot. Nano drug delivery system includes nanoparticles, nanocapsules, nanoliposomes, nanomicelles, nanosuspensions and nanoemulsions, with the advantages of reducing particle size, enlarging surface area, increasing drug permeability, improving intracorporeal circulation and distribution of the drug, enhancing drug targeting and so on. This article reviewed the latest progress at home and abroad about the studies and application of quercetin in nano drug delivery system, such as increasing solubility and dissolution, elevating bioavailability, raising drug stability, delaying drug release, enhancing skin permeability, promoting antioxidant capacity and improving therapeutic effect, in the hope of providing references for further research of quercetin preparations.
