Recent research advances of 1-deoxynojirimycin and its derivatives.
10.19540/j.cnki.cjcmm.20180125.010
- Author:
Ting-Ting TONG
1
;
Er-Hu ZHAO
1
;
Hai-Long GAO
1
;
Yong-Hui XU
1
;
Yong-Ju ZHAO
2
;
Gang FU
1
;
Hong-Juan CUI
1
Author Information
1. State Key Laboratory of Silkworm Genome Biology, College of Biotechnology, Southwest Univrsity, Chongqing 400716, China.
2. College of Animal Science and Technology, Southwest University, Chongqing 400716, China.
- Publication Type:Journal Article
- Keywords:
1-deoxynojirimycin;
bioactivties;
in silico target fishing;
pharmacokinetics;
source;
technique preparation process
- From:
China Journal of Chinese Materia Medica
2018;43(10):1990-1997
- CountryChina
- Language:Chinese
-
Abstract:
The 1-DNJ named 1-deoxynojirimycinis (2R,3R,4R,5S)-2-(hydroxymethyl) piperidine-3,4,5-triol, which is the nature active components existingin mulberryresources including leaves, stems, roots and silkworm larva, silkworm chrysalis, etc.The 1-deoxynojirimycin is a polyhydroxylated piperidine alkaloid, which was first found in Streptomyces as an antibiotic. Then the Japanese researchers isolated it from the mulberry root. 1-DNJ can inhibit postprandial hyperglycemia by suppressing intestinal alpha glucosidase. Therefore, 1-DNJ is often used to treat treating diabetes and complicating disease and to prevent obesity and weight-related disorders. With the development of the researches, 1-deoxynojirimycin and its derivtiv was discovered to possess anti-hyperglycemic, anti-virus, anti-tumor functions and so on. Therefore,based on our current studythe existing knowledge on source, technique preparation process, pharmacokinetics, bioactivties,and in silico target fishing of 1-DNJ were summarized, so that the researchers may use it to explore future perspective of research on 1-DNJ.
