A Cross-sectional Survey Assessing Carriage of Streptococcus pneumoniae in a Healthy Population in Xinjiang Uygur Autonomous Region of China.

Na Xie; Zhao Yun Chen; Tao Chen; Bing Qing Zhu; Li XU; Yuan Gao; Ai Yu Zhang; Pan Zhao; Ji Wen Liu; Zhu Jun Shao

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A Cross-sectional Survey Assessing Carriage of Streptococcus pneumoniae in a Healthy Population in Xinjiang Uygur Autonomous Region of China.

Author: Na XIE ^{1
,

2
,

3} ; Zhao Yun CHEN ⁴ ; Tao CHEN ⁵ ; Bing Qing ZHU ⁶ ; Li XU ⁶ ; Yuan GAO ⁶ ; Ai Yu ZHANG ⁶ ; Pan ZHAO ⁶ ; Ji Wen LIU ⁷ ; Zhu Jun SHAO ^{8
,

9}
Author Information

1. Department of Public Health, Xinjiang Medical University, Urumqi 830054, Xinjiang, China
2. National Institute for Communicable Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 102206, China
3. Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830011, Xinjiang, China.
4. Medical Laboratory Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang, China.
5. Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830011, Xinjiang, China.
6. National Institute for Communicable Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
7. Department of Public Health, Xinjiang Medical University, Urumqi 830054, Xinjiang, China.
8. National Institute for Communicable Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 102206, China
9. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310058, Zhejiang, China.
Publication Type:Letter
Keywords: China; Cross-sectional survey; Real-time PCR; Streptococcus pneumoniae carriage; Xinjiang
MeSH: Adolescent; Adult; Carrier State; epidemiology; microbiology; Child; Child, Preschool; China; epidemiology; Cross-Sectional Studies; Female; Humans; Infant; Male; Middle Aged; Pneumococcal Infections; epidemiology; microbiology; Prevalence; Real-Time Polymerase Chain Reaction; Serogroup; Streptococcus pneumoniae; classification; genetics; isolation & purification; Young Adult
From: Biomedical and Environmental Sciences 2018;31(3):233-237
CountryChina
Language:English
Abstract: The carriage rate and serotype distribution of Streptococcus pneumoniae (S. pneumoniae) in a healthy population in China remains unclear. In this study, we collected the oropharyngeal swabs from 513 individuals in Xinjiang, China. Real-time PCR targeting the lytA gene and 12 serotypes were assessed to identify S. pneumoniae carriage. The total carriage rate of S. pneumoniae was 70.4% (361/513). The most prevalent serotypes were 19B/F, 18B/C, 5, and 6A/B. The highest carriage rate of S. pneumoniae was noted in children aged 6-10 years (88.6%), which merits further attention. The co-colonization rate of two or more S. pneumoniae serotypes was 79.8% (264/331). This study aimed to investigate the baseline pneumococcal carriage rate among healthy individuals in China to improve our understanding of the epidemiology of S. pneumoniae.