Lipoprotein (a) as a Marker for Predicting the Presence and Severity of Coronary Artery Disease in Untreated Chinese Patients Undergoing Coronary Angiography.

Di Sun; Xi Zhao; Sha LI; Yan Zhang; Na Qiong WU; Cheng Gang Zhu; Yuan Lin Guo; Ying Gao; Ping Qing; Geng Liu; Qian Dong; Jian Jun LI

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Lipoprotein (a) as a Marker for Predicting the Presence and Severity of Coronary Artery Disease in Untreated Chinese Patients Undergoing Coronary Angiography.

Author: Di SUN ¹ ; Xi ZHAO ¹ ; Sha LI ¹ ; Yan ZHANG ¹ ; Na Qiong WU ¹ ; Cheng Gang ZHU ¹ ; Yuan Lin GUO ¹ ; Ying GAO ¹ ; Ping QING ¹ ; Geng LIU ¹ ; Qian DONG ¹ ; Jian Jun LI ¹
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1. Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Publication Type:Journal Article
Keywords: Chinese; Coronary artery disease; LDL-C; Lipoprotein (a)
MeSH: Aged; Asian Continental Ancestry Group; Biomarkers; Coronary Angiography; Coronary Artery Disease; diagnosis; Cross-Sectional Studies; Female; Humans; Lipoprotein(a); blood; Male; Middle Aged; Risk Factors
From: Biomedical and Environmental Sciences 2018;31(4):253-260
CountryChina
Language:English
Abstract:
OBJECTIVELow-density lipoprotein cholesterol (LDL-C) has been well known as the risk factor of coronary artery disease (CAD). However, the role of lipoprotein (a) [Lp(a)] in the development of CAD is of great interest but still controversial. Thus, we aim to explore the effect of Lp(a) on predicting the presence and severity of CAD in Chinese untreated patients, especially in combination with LDL-C.
METHODSWe consecutively recruited 1,980 non-treated patients undergoing coronary angiography, among which 1,162 patients were diagnosed with CAD. Gensini score (GS) was used to assess the severity of CAD. Lp(a) was measured by immunoturbidimetric method.
RESULTSPatients with CAD had higher level of LDL-C and Lp(a) compared with non-CAD (P < 0.05). Multivariable logistic regression revealed that Lp(a) > 205 mg/L (highest tertile) predicted 1.437-fold risk for CAD (95% CI: 1.108-1.865, P = 0.006) and 1.480-fold risk for high GS (95% CI: 1.090-2.009, P = 0.012) respectively. Interestingly, concomitant elevated level of Lp(a) and LDL-C conferred the highest risk for both presence [OR = 1.845, 95% CI: 1.339-2.541, P < 0.001] and severity [OR = 1.736, 95% CI: 1.188-2.538, P = 0.004] of CAD.
CONCLUSIONLipoprotein (a) is a useful marker for predicting the presence and severity of CAD, especially combined with LDL-C.