Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes: A Population-based Prospective Cohort Study of Inner Mongolians in China.

Qiao Yan Qiu; Bei Lei Zhang; Ming Zhi Zhang; Jia Hui WU; Jing Wen Zhou; Zhu Liang; Yong Hong Zhang; Shao Yan Zhang

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Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes: A Population-based Prospective Cohort Study of Inner Mongolians in China.

Author: Qiao Yan QIU ^{1
,

2} ; Bei Lei ZHANG ³ ; Ming Zhi ZHANG ³ ; Jia Hui WU ⁴ ; Jing Wen ZHOU ⁵ ; Zhu LIANG ⁶ ; Yong Hong ZHANG ³ ; Shao Yan ZHANG ³
Author Information

1. Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China
2. The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang, China.
3. Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
4. Wujin District Center for Disease Control and Prevention, Changzhou 213159, Jiangsu, China.
5. Nanjing Brain Hospital, Nanjing 210029, Jiangsu, China.
6. Kunshan Center for Disease Control and Prevention, Suzhou 215123, Jiangsu, China.
Publication Type:Journal Article
MeSH: Asian Continental Ancestry Group; Biomarkers; China; epidemiology; Cohort Studies; Diabetes Mellitus, Type 2; blood; epidemiology; genetics; Humans; Inflammation; metabolism; Insulin Resistance; genetics; physiology; Multivariate Analysis; Odds Ratio; Prospective Studies
From: Biomedical and Environmental Sciences 2018;31(4):300-305
CountryChina
Language:English
Abstract: This prospective study was designed to examine the combined influence of insulin resistance (IR) and inflammatory biomarker levels on type 2 diabetes mellitus (T2DM) among 1,903 Inner Mongolians. During follow-up, 205 (10.77%) participants developed T2DM, and the incidence of T2DM was higher among subjects with IR, elevated C-reactive protein (CRP), elevated sICAM-1, elevated sE-selectin, or the coexistences of IR with elevated CRP, elevated sICAM-1, elevated sE-selectin, and elevated angiotensin II (all P < 0.05) compared with patients without IR or any elevated biomarkers. In multivariate analysis, the odd ratios [OR, (95% confidence intervals)] for these conditions were 1.944 (1.405-2.691), 2.003 (1.449-2.767), 1.706 (1.232-2.362), 1.560 (1.123-2.165), 2.708 (1.809-4.054), 1.885 (1.155-3.078), 2.101 (1.340-3.295), and 2.260 (1.426-3.582), respectively. Our findings demonstrated that IR and elevated inflammatory biomarkers were associated with T2DM, and that the coexistence of IR and elevated inflammatory biomarkers increased the risk of T2DM.