Acceptance of Chemo-prophylaxis for Latent Tuberculosis Infection among High School/College Student Contacts of Tuberculosis Patients in Shanghai, China.

Yang LI; Yi Hui Zheng; Li Ping LU; Mei Xia Yang; Chang Ming Zhou; Zheng An Yuan; Yi HU; Biao XU

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Acceptance of Chemo-prophylaxis for Latent Tuberculosis Infection among High School/College Student Contacts of Tuberculosis Patients in Shanghai, China.

Author: Yang LI ¹ ; Yi Hui ZHENG ² ; Li Ping LU ³ ; Mei Xia YANG ⁴ ; Chang Ming ZHOU ¹ ; Zheng An YUAN ⁵ ; Yi HU ¹ ; Biao XU ^{6
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Author Information

1. Department of Epidemiology and Key Laboratory of Public Health Safety (Ministry of Education), School of Public Health, Fudan University, Shanghai 200032, China.
2. Putuo District Center for Disease Control and Prevention, Shanghai 200333, China.
3. Songjiang District Center for Disease Control and Prevention, Shanghai 201620, China.
4. Xuhui District Center for Disease Control and Prevention, Shanghai 200237, China.
5. Shanghai Center for Disease Control and Prevention , Shanghai 200336, China.
6. Department of Epidemiology and Key Laboratory of Public Health Safety (Ministry of Education), School of Public Health, Fudan University, Shanghai 200032, China
7. Department of Public Health Sciences, Karolinska Institutet, Stockholm 17177, Sweden.
Publication Type:Journal Article
MeSH: Adolescent; Adult; Antitubercular Agents; administration & dosage; therapeutic use; China; epidemiology; Contact Tracing; Female; Humans; Latent Tuberculosis; drug therapy; epidemiology; Male; Students; Tuberculosis, Pulmonary; drug therapy; epidemiology; prevention & control; transmission; Universities; Young Adult
From: Biomedical and Environmental Sciences 2018;31(4):317-321
CountryChina
Language:English
Abstract: Student contacts of tuberculosis (TB) cases are susceptible to latent tuberculosis infection (LTBI), and chemo-prophylaxis can reduce the risk of active TB among them. This study aimed to assess the acceptance of chemo-prophylaxis for LTBI among students, and their concerns regarding TB and its preventive treatment. A total of 560 students contacts were included in the investigation. The extent of contact was categorized from high to low (4 levels) with 12.9% of the students being close contacts. About 87.0% of the students were willing to receive chemo-prophylaxis if diagnosed with, LTBI, whereas 73 students declined. Students with a higher level of knowledge about TB (aOR = 1.11) or close contact with TB patients (aOR = 4.30) were more likely to accept treatment. To conclude, education regarding TB transmission is necessary. Moreover, LTBI detection should be integrated into the current school-based TB contact investigation.