Decrease in Serum Amyloid a Protein Levels Following Three-month Stays in Negatively Charged Particle-dominant Indoor Air Conditions.

Suni Lee; Shoko Yamamoto; Yasumitsu Nishimura; Hidenori Matsuzaki; Kei Yoshitome; Tamayo Hatayama; Miho Ikeda; Min YU; Nagisa Sada; Naoko Kumagai-takei; Takemi Otsuki

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Decrease in Serum Amyloid a Protein Levels Following Three-month Stays in Negatively Charged Particle-dominant Indoor Air Conditions.

Author: Suni LEE ¹ ; Shoko YAMAMOTO ¹ ; Yasumitsu NISHIMURA ¹ ; Hidenori MATSUZAKI ¹ ; Kei YOSHITOME ¹ ; Tamayo HATAYAMA ¹ ; Miho IKEDA ¹ ; Min YU ^{2
,

3
,

4} ; Nagisa SADA ^{2
,

5} ; Naoko KUMAGAI-TAKEI ¹ ; Takemi OTSUKI ¹
Author Information

1. Department of Hygiene, Kawasaki Medical School, 577 Mastushima, Kurashiki 701-0192, Japan.
2. Department of Hygiene, Kawasaki Medical School, 577 Mastushima, Kurashiki 701-0192, Japan
3. Department of Occupational and Environmental Health Science, School of Public Health, School of Public Health, Peking University Health Science Center, Beijing 100191, China
4. Department of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, Zhejiang, China.
5. Department of Biophysical Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushimanaka, Kita-Ku, Okayama 700-8530, Japan.
Publication Type:Journal Article
Keywords: Biomarker; Cardiovascular disease; Indoor air; Negatively charged particle; Serum amyloid A
MeSH: Adult; Air; analysis; Air Pollution, Indoor; Environmental Monitoring; Female; Housing; Humans; Male; Serum Amyloid A Protein; metabolism
From: Biomedical and Environmental Sciences 2018;31(5):335-342
CountryChina
Language:English
Abstract:
OBJECTIVEThe changes in serum adipokines and cytokines related to oxidative stress were examined during 3 months 'Off to On' and 'On to Off' periods using negatively charged particle-dominant indoor air conditions (NCPDIAC).
METHODSSeven volunteers participated in the study, which included 'OFF to 3 months ON' periods (ON trials) for a total of 16 times, and 'ON to 3 months OFF' (OFF trials) periods for a total of 13 times.
RESULTSWith the exception of one case, serum amyloid A (SAA) levels decreased significantly during the ON trials.
CONCLUSIONConsidering that SAA is an acute phase reactive protein such as C reactive protein (CRP), this observed decrease might indicate the prevention of cardiovascular and atherosclerotic changes, since an increase in high-sensitive CRP is associated with the subsequent detection of these events.