A Case of Villous Adenoma with Depletion Syndrome.
- Author:
Nam Soo CHOI
1
;
Hyo Jong KIM
;
Jung Hwan LEE
;
Seung Ho LEE
;
Chong Oh PARK
;
Won Wook LEE
;
Suk Ho DONG
;
Byung Ho KIM
;
Young Woon CHANG
;
Jung Il LEE
;
Rin CHANG
Author Information
1. Department of Gastroenterology, College of Medicine, Kyung Hee University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Villous adenoma;
Secretory diarrhea;
Depletion syndrome
- MeSH:
Acidosis;
Adenoma, Villous*;
Alkalosis;
Denial (Psychology);
Diarrhea;
Dinoprostone;
Epithelium;
Hypokalemia;
Hyponatremia;
Ligases;
Palliative Care;
Potassium;
Rectum;
Sodium;
Vomiting
- From:Korean Journal of Gastrointestinal Endoscopy
1998;18(1):107-110
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Massive secretory diarrhea with pre-renal insufficiency, hyponatremia, hypokalemia and metabolic alkalosis or acidosis is associated with some large villous adenomas of the rectum and is called with depletion syndrome. This characteristic fluid and electrolyte depletion syndrome is caused by secretion of sodium, potassium, and fluid from the tumor. PGE2 formation in the villous adenoma appears to be the cause of fluid secretion by the abnormal tumor epithelium. Surgical removal of villous adenoma is the only promising therapy, In case of inoperability, denial of surgical intervention or just for palliative treatment prior to surgery, the use of PG synthetase inhibitors may facilitate the correction of severe fluid-electrolyte deficits. We reported a case of large villous adenoma of the rectum with depletion syndrome aceompanied by secretory diarrhea and fluid and electrolyte depletion with metabolic alkalosis due to severe vomiting.
