Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography.

Qi Zhao; Wen Li Yang; Xiao Na Wang; Ruikang K Wang; Qi Sheng You; Zhong Di Chu; Chen Xin; Meng Yu Zhang; Dong Jun LI; Zi Yang Wang; Wei Chen; Yi Feng LI; Rui Cui; Lin Shen; Wen Bin Wei

Return

Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography.

Author: Qi ZHAO ^{1
,

2} ; Wen Li YANG ^{1
,

2} ; Xiao Na WANG ^{3
,

4} ; Ruikang K WANG ^{3
,

5
,

6} ; Qi Sheng YOU ^{3
,

4} ; Zhong Di CHU ⁷ ; Chen XIN ^{3
,

4} ; Meng Yu ZHANG ^{1
,

2} ; Dong Jun LI ^{1
,

2} ; Zi Yang WANG ^{1
,

2} ; Wei CHEN ^{1
,

2} ; Yi Feng LI ^{1
,

2} ; Rui CUI ^{1
,

2} ; Lin SHEN ^{1
,

2} ; Wen Bin WEI ^{1
,

2}
Author Information

1. Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University
2. Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100730, China.
3. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University
4. Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China.
5. Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China
6. Department of Bioengineering, University of Washington, Seattle Washington 98195, United States of America.
7. Department of Bioengineering, University of Washington, Seattle Washington 98195, United States of America.
Publication Type:Journal Article
Keywords: Macular blood flow; Optical coherence tomography angiography; Repeatability; Reproducibility; Retinal superficial capillary; Vascular quantification
MeSH: Adult; Cohort Studies; Evaluation Studies as Topic; Female; Fluorescein Angiography; standards; Healthy Volunteers; Humans; Image Processing, Computer-Assisted; Male; Microvessels; diagnostic imaging; Middle Aged; Prospective Studies; Reproducibility of Results; Retina; diagnostic imaging; Retinal Vessels; diagnostic imaging; Tomography, Optical Coherence; standards; Young Adult
From: Biomedical and Environmental Sciences 2018;31(6):407-412
CountryChina
Language:English
Abstract:
OBJECTIVEThe aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography (OCTA) based on optical microangiography (OMAG) measurements of macular vessels in normal eyes.
METHODSIn this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA (Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.) scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network: vessel area density (VAD), vessel skeleton density (VSD), vessel diameter index (VDI), vessel perimeter index (VPI), vessel complexity index (VCI), flux, and foveal avascular zone (FAZ). Coefficient of variation (CV) and intraclass correlation coefficient (ICC) were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility.
RESULTSThe measurements showed high repeatability [CVs ⪕ 4.2% (intravisit) and ⪕ 4.6% (intervisit)] and interobserver reproducibility (ICCs ⪖ 0.923) for all parameters.
CONCLUSIONThis study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes.