Association between IgG N-glycans and Nonalcoholic Fatty Liver Disease in Han Chinese.

Zhong Yao Zhao; Di Liu; Wei Jie Cao; Ming Sun; Man Shu Song; Wei Wang; You Xin Wang

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Association between IgG N-glycans and Nonalcoholic Fatty Liver Disease in Han Chinese.

Author: Zhong Yao ZHAO ¹ ; Di LIU ¹ ; Wei Jie CAO ¹ ; Ming SUN ¹ ; Man Shu SONG ¹ ; Wei WANG ^{2
,

3} ; You Xin WANG ^{2
,

3}
Author Information

1. Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, China.
2. Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, China
3. School of Medical and Health Sciences, Edith Cowan University, Perth WA 6027, Australia.
Publication Type:Journal Article
MeSH: Biomarkers; blood; China; Cross-Sectional Studies; Diabetes Mellitus, Type 2; blood; complications; Female; Glycosylation; Humans; Immunoglobulin G; blood; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; blood; etiology; Obesity; blood; complications; Odds Ratio; Polysaccharides; blood; Risk Factors
From: Biomedical and Environmental Sciences 2018;31(6):454-458
CountryChina
Language:English
Abstract: Nonalcoholic fatty liver disease (NAFLD) is a major public health issue worldwide. Immunoglobulin G (IgG) N-glycans are associated with risk factors for NAFLD, such as obesity and diabetes. A cross-sectional study involving 500 Han Chinese adults recruited from a community in Beijing was carried out to explore the association between IgG N-glycans and NAFLD. IgG N-glycosylation was significantly associated with NAFLD, with the disease showing a negative correlation with galactosylation (GP14, GP14n, and G2n), positive correlation with fucosylation (FBG2n/G2n), and positive correlation with bisecting N-acetylglucosamine (GlcNAc) [FBG2n/FG2n and FBG2n/(FG2n+FBG2n)], after controlling age, gender, and prevalence of obesity, type 2 diabetes mellitus, hypertension, and hyperlipidemia. In other words, the present study showed a possible association between NAFLD and the loss of galactose and elevations of fucose and bisecting GlcNAc. Aberrant IgG glycosylation might therefore be a potential biomarker for the primary or secondary prevention of NAFLD.