A Retrospective Study of Culture-confirmed Mycobacterial Infection among Hospitalized HIV-infected Patients in Beijing, China.

Xiu Ying Zhao; Zhao Ying Zeng; Wen Hao Hua; Yan Hua YU; Cai Ping Guo; Xiu Qin Zhao; Hai Yan Dong; Jie Liu; Kang Lin Wan

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A Retrospective Study of Culture-confirmed Mycobacterial Infection among Hospitalized HIV-infected Patients in Beijing, China.

Author: Xiu Ying ZHAO ¹ ; Zhao Ying ZENG ² ; Wen Hao HUA ³ ; Yan Hua YU ⁴ ; Cai Ping GUO ⁴ ; Xiu Qin ZHAO ⁵ ; Hai Yan DONG ⁵ ; Jie LIU ⁵ ; Kang Lin WAN ⁵
Author Information

1. Beijing Tsinghua Changgung Hospital, School of Clinic Medicine, Tsinghua University, Beijing 102218, China.
2. Department of Clinical Laboratory, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
3. Beijing Di'tan Hospital, Capital Medical University, Beijing 102206, China.
4. Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
5. National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Beijing 102206, China.
Publication Type:Journal Article
MeSH: AIDS-Related Opportunistic Infections; epidemiology; microbiology; Adult; Beijing; Coinfection; Extensively Drug-Resistant Tuberculosis; epidemiology; microbiology; Female; HIV Infections; epidemiology; microbiology; Hospitals, Urban; Humans; Male; Mycobacterium Infections, Nontuberculous; epidemiology; microbiology; Mycobacterium tuberculosis; isolation & purification; Nontuberculous Mycobacteria; isolation & purification; Prevalence; Retrospective Studies; Sputum; microbiology; Tuberculosis, Multidrug-Resistant; epidemiology; microbiology; Tuberculosis, Pulmonary; epidemiology; microbiology
From: Biomedical and Environmental Sciences 2018;31(6):459-462
CountryChina
Language:English
Abstract: A retrospective analysis was performed in two major HIV/AIDS referral hospitals in Beijing to evaluate the prevalence of Mycobacterium tuberculosis (MTB) and non-tuberculous mycobacterial (NTM) infections in HIV-infected patients. A total of 627 patients' data were reviewed, and 102 (16.3%) patients were diagnosed with culture-confirmed mycobacterial infection, including 84 with MTB, 16 with NTM, and 2 with both MTB and NTM. The most frequent clinical complication by mycobacterial infection was pulmonary infection (48/102, 47.1%). The overall rates of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) were 11.9% and 3.4%, respectively. This study underlines the urgent need to intensify screening for mycobacteria coinfection with HIV and to prevent the spread of drug-resistant TB among HIV-infected patients.