MMP Inhibitor Ilomastat Improves Survival of Mice Exposed to γ-Irradiation.

Xiao Man LI; Yong Tan; Chun Qian Huang; Meng Chuan XU; Qian LI; Dong Pan; Bao Quan Zhao; Bu Rong HU

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MMP Inhibitor Ilomastat Improves Survival of Mice Exposed to γ-Irradiation.

Author: Xiao Man LI ^{1
,

2
,

3} ; Yong TAN ⁴ ; Chun Qian HUANG ⁴ ; Meng Chuan XU ⁴ ; Qian LI ⁴ ; Dong PAN ⁵ ; Bao Quan ZHAO ⁴ ; Bu Rong HU ⁵
Author Information

1. CAS Key Laboratory of Heavy Ion Radiation Biology and Medicine & Key Laboratory of Space Radiobiology of Gansu Province, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China
2. State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
3. University of Chinese Academy of Sciences, Beijing 100049, China.
4. State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China.
5. CAS Key Laboratory of Heavy Ion Radiation Biology and Medicine & Key Laboratory of Space Radiobiology of Gansu Province, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China.
Publication Type:Journal Article
MeSH: Acute Radiation Syndrome; blood; immunology; prevention & control; Animals; Blood Cells; drug effects; radiation effects; Dose-Response Relationship, Drug; Gamma Rays; adverse effects; Hydroxamic Acids; therapeutic use; Indoles; therapeutic use; Matrix Metalloproteinase Inhibitors; therapeutic use; Mice; Radiation Injuries, Experimental; blood; immunology; prevention & control; Radiation-Protective Agents; therapeutic use; Spleen; drug effects; immunology; radiation effects; Survival Analysis; Whole-Body Irradiation
From: Biomedical and Environmental Sciences 2018;31(6):467-472
CountryChina
Language:English
Abstract: There is still a need for better protection against or mitigation of the effects of ionizing radiation following conventional radiotherapy or accidental exposure. The objective of our current study was to investigate the possible roles of matrix metalloproteinase inhibitor, ilomastat, in the protection of mice from total body radiation (TBI), and the underlying protective mechanisms. Ilomastat treatment increased the survival of mice after TBI. Ilomastat pretreatment promoted recovery of hematological and immunological cells in mice after 6 Gy γ-ray TBI. Our findings suggest the potential of ilomastat to protect against or mitigate the effects of radiation.