Association between the HOTAIR Polymorphism and Susceptibility to Lead Poisoning in a Chinese Population.

Lin Chen; Qiu Ni Zhao; Xiu Rong Qian; Bao Li Zhu; En Min Ding; Bo Shen Wang; Heng Dong Zhang; Hong Yang

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Association between the HOTAIR Polymorphism and Susceptibility to Lead Poisoning in a Chinese Population.

Author: Lin CHEN ^{1
,

2} ; Qiu Ni ZHAO ³ ; Xiu Rong QIAN ⁴ ; Bao Li ZHU ⁵ ; En Min DING ⁵ ; Bo Shen WANG ⁶ ; Heng Dong ZHANG ⁵ ; Hong YANG ⁶
Author Information

1. Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China
2. Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210028, Jiangsu, China.
3. Nanjing Center for Disease Prevention and Control, Nanjing 210003, Jiangsu, China.
4. School of Public Health, Nantong University, Nantong 226019, Jiangsu, China.
5. Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210028, Jiangsu, China.
6. Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China.
Publication Type:Journal Article
MeSH: Adult; Alleles; Asian Continental Ancestry Group; genetics; Female; Genetic Predisposition to Disease; Genetic Testing; Humans; Lead Poisoning; genetics; Male; Occupational Diseases; genetics; Polymorphism, Single Nucleotide; RNA, Long Noncoding; genetics
From: Biomedical and Environmental Sciences 2018;31(6):473-478
CountryChina
Language:English
Abstract: This study explored the association between the lncRNA HOTAIR polymorphism and susceptibility to lead poisoning in a Chinese population. We speculated that lead poisoning caused elevated levels of oxidative stress, which, in turn, activate the HOTAIR gene to cause apoptosis. Three lncRNA HOTAIR tagSNPs (rs7958904, rs4759314, and rs874945) were genotyped by TaqMan genotyping technology in 113 lead-sensitive and 113 lead-resistant Chinese workers exposed to lead. Rs7958904 was significantly associated with susceptibility to lead poisoning (P = 0.047). The rs7958904 G allele had a protective effect compared with the C allele and reduced the risk of lead poisoning (P = 0.016). Rs7958904 may act as a potential biomarker for predicting the risk of lead poisoning and distinguishing lead-sensitive individuals from lead-resistant individuals.