Quality evaluation of Rhei Radix et Rhizoma decoction.
10.19540/j.cnki.cjcmm.20171023.008
- Author:
Man-Jia ZHAO
1
;
Jung CHAO
2
;
Yun-Tao DAI
2
;
Shi-Lin CHEN
2
;
Qi LI
3
;
Zi-Quan FAN
4
;
Dan-Dan WANG
4
;
Takehisa TOMODA
5
Author Information
1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
2. Institute of Chinese Materia Medica, China Academy of Chinese Medicinal Sciences, Beijing 100700, China.
3. Shanghai Traditional Chinese Medicine Co., Ltd., Shanghai 200002, China.
4. Waters Corporation(Shanghai), Shanghai 201206, China.
5. Tsumura & Co., Tokyo 107-8521, Japan.
- Collective Name:null
- Publication Type:Journal Article
- Keywords:
Rhei Radix et Rhizoma;
decoction of single medicinal herb;
extraction ratio;
fingerprint;
mass spectrometry;
quality evaluation;
transfer rate
- From:
China Journal of Chinese Materia Medica
2018;43(5):861-867
- CountryChina
- Language:Chinese
-
Abstract:
Decoction of single medicinal herb is a reference for the standardization of different dosage forms of Chinese medicine and it provides a new direction for solving the problems existing in the quality of Chinese medicinal granules such as no uniform dosage form and no clear quality standard. In this paper, the quality evaluation method of standard decoction of rhubarb was established to provide reference for the quality control of common dosage forms such as clinical decoction and formula granule. 10 batches of representative Rhei Radix et Rhizoma were collected to establish UPLC fingerprints were established. The chemical structures of main peaks were identified with ultra-performance liquid chromatography with quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and the main components in the decoction were Anthraquinones. The extraction ratio of the standard decoction was (28.1±3.8)% and the transfer rate was (19.9±6.3)%. The method for the quality evaluation of standard decoction of Rhei Radix et Rhizoma was established in this study, providing reference for the quality control method of terminal products from decoction of Rhei Radix et Rhizoma.
