Proteomics and its application to determine mechanism of action of traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20180118.002
- Author:
Ping XIN
1
;
Hai-Xue KUANG
1
;
Xiao-Liang LI
1
;
Yu WANG
1
;
Ben-Mei ZHANG
1
;
He BU
1
;
Zhi-Bin WANG
1
;
Yong-Hai MENG
1
;
Yan-Hong WANG
1
;
Qiu-Hong WANG
2
Author Information
1. Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang Key Laboratory of Traditional Chinese Medicine Pharmacodynamic Material, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
2. Guangdong Pharmaceutical University, Guangzhou 510006, China.
- Publication Type:Journal Article
- Keywords:
mechanisms of action;
proteomics;
traditional Chinese medicine
- From:
China Journal of Chinese Materia Medica
2018;43(5):904-912
- CountryChina
- Language:Chinese
-
Abstract:
There is no doubt that the traditional Chinese medicine(TCM) is effective, practical and scientific after it was used for thousands of years. However, the mechanisms of action of many TCM are still unclear because of their multi-component, multi-target and multi-level features, which hinder the modernization and internationalization of the TCM. Proteomics is to analyze the composition and activity of intracellular proteins which are changing dynamically from a holistic perspective. It is consistent with the holistic and dynamic views of the TCM and brings about the hope of clarifying the mechanism of action of the TCM. In recent years, great progress has been made in the application of proteomics to determine the mechanism of the TCM. This article introduced the core technologies of proteomics and systematically summarized the applications of proteomics in the study of the mechanism of the Chinese medicinal formulae, single Chinese medicine and monomeric compounds from the TCM to provide innovative ideas and methods for reference.
