Hypolipidemic effect of Coptis chinensis and C. deltoidea on type 2 diabetes rats through SCAP/SREBP-1c signal pathway.
10.19540/j.cnki.cjcmm.20180208.003
- Author:
Rui-Ying LIU
1
;
Si-Yuan ZHANG
1
;
Bin REN
1
;
Yu-Man HE
1
;
Jian GU
2
;
Rui TAN
3
Author Information
1. College of Life Science and Engineering, Southwest Jaotong University, Chengdu 610031, China.
2. School of Pharmacy, Southwest University for Nationalities, Chengdu 610051, China.
3. Medical College, Southwest Jaotong University, Chengdu 610031, China.
- Publication Type:Journal Article
- Keywords:
Coptis chinensis;
Coptis deltoidea;
insulin resistance;
lipid metabolism;
signal pathway;
type 2 diabetes mellitus
- From:
China Journal of Chinese Materia Medica
2018;43(10):2129-2133
- CountryChina
- Language:Chinese
-
Abstract:
The type 2 diabetes rat model was induced with high-sugar and high-fat diet combined with low-dose STZ. This study investigated the hypolipidemic mechanism of Coptis chinensis and C. deltoidea. After 30 days of administration, HOMA-IR and the content of TG in serum were detected, and the expressions of SCAP, SREBP-1c were tested by the method of Western blot and Real-time PCR analysis. The test results showed that both components can significantly alleviate insulin resistance and down-regulate the expressions of SREBP-1c and SCAP in liver tissue of type two diabetes mellitus. Compared with the control group, there were significant differences in relevant protein expression (<0.05, <0.01). This indicates that the inhibition of SREBP-1c and SCAP expressions may be the hypolipidemic mechanism of Coptidis Rhizoma on type 2 diabetes mellitus. The results also showed that C. deltoidea has a better efficacy in lipid elimination, but a weaker hypoglycemic effect against C. chinensis.
