Expression of phosphoglycerate kinase 1 in endometrial carcinoma and its association with patients' outcome.
- Author:
Li LIN
1
;
Qing-Ping JIANG
;
Dan LIN
;
Wei CHEN
;
Hui-Ping JIANG
;
Chun-Hua LIU
;
Yan-Yi XIAO
;
Li-Tong ZHU
;
Sui-Qun GUO
Author Information
- Publication Type:Journal Article
- From: Journal of Southern Medical University 2018;38(4):471-476
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of phosphoglycerate kinase 1 (PGK1) and its prognostic value in endometrial carcinoma (EC).
METHODSThe expression of PGK1 was detected immunohistochemically in 30 normal endometrium and 130 EC specimens. The relationship between PGK1 protein expression and the clinicopathological features of the patients was evaluated.
RESULTSImmunohistochemical analysis revealed low PGK1 expression in 55.4% (72/130) and high PGK1 expression in 44.6% (58/130) of the EC specimens, as compared with the rates of 90% (27/30) and 10% (3/30) in normal endometrium, respectively (P<0.001). PGK1 expression was significantly correlated with FIGO stage (P<0.001), histological grade (P=0.002) and lymph node metastasis (P<0.001). Kaplan-Meier survival analysis indicated that patients with a high PGK1 expression had a shorter overall survival rate than those with a low PGK1 expression (P<0.001). Multivariate analysis showed that a high PGK1 expression was not the independent predictor of the prognosis of EC (P=0.077).
CONCLUSIONA high expression of PGK1 is associated with aggressive and metastatic behaviors of EC, and detection of PGK1 provides assistance in evaluating the prognosis of patients with EC.
