Network pharmacology of flavonoids in Sophora alopecuroides.
10.19540/j.cnki.cjcmm.20180412.002
- Author:
Dong XIAO
1
;
Gai-Gai ZHUANG
2
;
Yuan-Jie LI
3
;
Quan-Xia LIU
2
;
Xiao-Juan GAO
1
;
Jing-Jiao YONG
1
;
Xia ZHANG
1
;
Jian-Jun ZHAO
1
;
Han-Qing WANG
1
Author Information
1. College of Pharmacy， Ningxia Medical University， Yinchuan 750004， China.
2. General Hospital of Ningxia Medical University， Yinchuan 750004， China.
3. College of Basic Medical， Ningxia Medical University， Yinchuan 750004， China.
- Publication Type:Journal Article
- Keywords:
Pharm Mapper;
Sophora alopecuroides;
flavonoids;
material basis;
network pharmacology;
target
- From:
China Journal of Chinese Materia Medica
2018;43(16):3353-3361
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this paper was to investigate the potential pharmacological effect of flavonoids in Sophora alopecuroides by network pharmacology. This study predicted the potential targets of 11 flavonoids of S. alopecuroides with help of reversed pharmacophore matching target recognition service platform (PharmMapper). The pathway information was acquired from DAVID and KEGG databases. Cytoscape software was used to construct the "ingredient-target-pathway" network of flavonoids active components of S. alopecuroides. The flavonoids active components of S. alopecuroides play anti-inflammatory, blood sugar regulating and other pharmacological effects by regulating 62 targets (such as INSR，KDR，MET) and intervening 44 pathways, such as B cell receptor signaling pathway, insulin signaling pathway, neurotrophin signaling pathway, and T cell receptor signaling pathway. In this study, the mechanism of "muti components-multitargets-multiple pathway" of flavonoids was studied. It reflects the multi-components, multi-targets and multiple pathway features of traditional Chinese medicine. Meanwhile, it provides a scientific basis for the elucidation the mechanism of S. alopecuroides as a medicine, and the development and utilization resources of S. alopecuroides.
