Relationship between Autophagy and Curcumin-induced Anticancer Effect.
10.3881/j.issn.1000-503X.10002
- Author:
Ji-Ming XU
1
;
Hao-Ran DING
1
;
Zhi-Xin LI
1
;
Hong-Jun WANG
1
Author Information
1. Department of Histology and Embryology,Jilin Medical University,Jilin 132013,China.
- Publication Type:Journal Article
- From:
Acta Academiae Medicinae Sinicae
2018;40(4):568-572
- CountryChina
- Language:Chinese
-
Abstract:
Curcumin is a polyphenol extracted from turmeric rhizome and has multiple pharmacological roles. Recently,its anticancer properties have been recognized. Also,curcumin regulates autophagy in tumor cells via signaling pathways including AMP-activated protein kinase,mammalian target of rapamycin,transcription factor EB,Beclin-1,B-cell lymphoma 2,and endoplasmic reticulum stress. Considering the complicated crosstalk between autophagy and apoptosis,in this article we summaize the mechanism of curcumin-induced autophagy and its effect on apoptosis,with an attempt to provide insights on tumor therapy.
