Combined Effects of Electroacupuncture and Behavioral Training on Learning-Memory Ability and Event-Related Potential P300 in Rats with Mid/Advanced Cerebral Infarction.

Qian YU; Xiao-hong LI; Wei Jiang; Ya-mei LI; Xiao-dong Duan; Wei Wei; Jing FU; Lin Huang

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Combined Effects of Electroacupuncture and Behavioral Training on Learning-Memory Ability and Event-Related Potential P300 in Rats with Mid/Advanced Cerebral Infarction.

Author: Qian YU ¹ ; Xiao-Hong LI ² ; Wei JIANG ³ ; Ya-Mei LI ¹ ; Xiao-Dong DUAN ³ ; Wei WEI ⁴ ; Jing FU ¹ ; Lin HUANG ¹
Author Information

1. Department of Rehabilitation Medicine, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China.
2. Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
3. Department of Rehabilitation Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
4. Electrophysiology Room of Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
Publication Type:Journal Article
Keywords: Cerebral Infarction; Electroacupuncture; Event-Related Potentials; Exercise Therapy; P300; Rats
MeSH: Acupuncture Points; Animals; Cerebral Infarction; Disease Models, Animal; Electroacupuncture; Evoked Potentials; Humans; Rats; Rats, Inbred ACI; Rats, Sprague-Dawley
From: Chinese Medical Journal 2018;131(18):2172-2178
CountryChina
Language:English
Abstract:
BackgroundThe effectiveness of the combination of electroacupuncture (EA) and behavioral training (BT) for mid/advanced cerebral infarction (M/ACI) and related mechanisms remains unclear. This study aimed to investigate the combined effects on the learning-memory ability and event-related potential P300 in rats with M/ACI.
MethodsEighty rats with M/ACI were divided into Group Model (M), Group EA, Group BT, and Group EA-BT (n = 20) according to the random number with five healthy rats in Group Control (CON). On the 6 week after modeling, EA, BT, and EA-BT were given to Group EA, Group BT, and Group EA-BT, respectively, whereas Group M and Group CON were not given any intervention. Y-maze test and P300 were recorded before and after the intervention.
ResultsAfter intervention, the P300 latency was lower and the amplitude was higher in the Group EA-BT, Group EA, and Group BT than before (for latency, t = -7.638, -4.334, and -5.916; for amplitude, t = 8.125, 3.846, and 5.238; P < 0.01), with Group EA-BT superior to Group EA (for latency, t = -3.708; for amplitude, t = 3.653; P < 0.01) and Group BT (for latency, t = -2.067; for amplitude, t = 2.816; P < 0.05), with no significant difference between Group BT and EA (for latency, t = -1.439; for amplitude, t = 1.075; P > 0.05). While the performances of Y-maze tests in the Group EA-BT, Group EA, and Group BT were all better than before (t = 10.359, 4.520, and 7.791, P < 0.01), with Group EA-BT better than Group EA (t = 5.627, P < 0.01) and Group BT (t = 2.913, P < 0.01) respectively, and Group BT better than Group EA (t = 2.912, P < 0.01).
ConclusionEA or BT can affect P300 in rats with M/ACI, and the combination of these two methods can significantly improve the learning-memory ability.