Relationship between expression of peripheral blood HLA-DR, CD4CD25 regulatory T cells, IL-17 and IL-27 with liver damage in children with human cytomegalovrius infection.
- Author:
Li-Li ZHU
1
;
Ling XU
;
Jun WANG
Author Information
- Publication Type:Journal Article
- MeSH: CD4 Antigens; immunology; Cytomegalovirus; physiology; Cytomegalovirus Infections; blood; complications; genetics; Female; Flow Cytometry; HLA-DR Antigens; genetics; immunology; Humans; Infant; Interleukin-17; blood; genetics; Interleukin-2 Receptor alpha Subunit; immunology; Interleukins; blood; genetics; Liver; injuries; metabolism; Liver Diseases; blood; etiology; immunology; Male; T-Lymphocytes, Regulatory; immunology
- From: Chinese Journal of Contemporary Pediatrics 2018;20(7):554-558
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationship between the expression of peripheral blood HLA-DR, CD4CD25 regulatory T cells, IL-17 and IL-27 with liver damage in children with human cytomegalovirus (HCMV) infection.
METHODSTwenty-one HCMV children with liver damage and twenty-one HCMV children without liver damage were enrolled in this study. The expression of peripheral blood HLA-DR and CD4CD25 regulatory T cells was detected by flow cytometry. Plasma levels of IL-17 and IL-27 were measured using ELISA.
RESULTSThe plasma levels of IL-17 and IL-27 in children with liver damage were significantly higher than in those without liver damage, while the expression of peripheral blood CD4CD25 regulatory T cells was lower than in those without liver damage (P<0.05). Plasma IL-17 and IL-27 levels were negatively correlated with the expression of peripheral blood CD4CD25 regulatory T cells (P<0.01).
CONCLUSIONSImmune imbalance mediated by CD4CD25 regulatory T cells and over-expression of IL-17 and IL-27 may be involved in the pathogenesis of liver damage in children with HCMV infection.
