Preventive effect of caffeine on bronchopulmonary dysplasia in preterm infants.
- Author:
Yang LIU
1
;
Wen-Bin DONG
Author Information
1. Department of Neonatology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China. dongwenbin2000@163.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Bronchopulmonary Dysplasia;
genetics;
metabolism;
physiopathology;
prevention & control;
Caffeine;
administration & dosage;
Humans;
Infant, Premature;
growth & development;
metabolism;
Infant, Premature, Diseases;
genetics;
metabolism;
physiopathology;
prevention & control;
Oxidative Stress;
drug effects
- From:
Chinese Journal of Contemporary Pediatrics
2018;20(7):598-602
- CountryChina
- Language:Chinese
-
Abstract:
With the increase in the rescue success rate of critically ill preterm infants and extremely preterm infants, the incidence rate of bronchopulmonary dysplasia (BPD) is increasing year by year. BPD has a high mortality rate and high possibility of sequelae, which greatly affects the quality of life of preterm infants and brings a heavy burden to their families, and so the treatment of BPD is of vital importance. At present, no consensus has been reached on the treatment measures for BPD. However, recent studies have shown that early application of caffeine can prevent BPD. With reference to the latest studies on the effect of caffeine in the prevention of BPD, this article reviews the mechanism of action of caffeine in reducing pulmonary inflammation, improving morphological abnormalities of lung injury, reducing oxidative stress injury, and improving pulmonary function.
