Insomnia in Relation to Suicide and Serotonin in Patients with Major Depressive Disorder.
- Author:
Young Min PARK
;
Seung Gul KANG
;
Heon Jeong LEE
;
Leen KIM
- Publication Type:Original Article
- Keywords:
Insomnia;
Suicide;
Serotonin;
LDAEP
- MeSH:
Antidepressive Agents;
Depression;
Depressive Disorder, Major*;
Evoked Potentials;
Evoked Potentials, Auditory;
Humans;
Serotonin*;
Sleep Initiation and Maintenance Disorders*;
Suicide*;
Weights and Measures
- From:Sleep Medicine and Psychophysiology
2014;21(1):29-32
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The aim of current study is to evaluate the relationship between sleep, suicide and serotonin using some scales and loudness dependence of auditory evoked potentials (LDAEP). METHODS: Total 65 patients who met the criteria for major depressive disorder were enrolled in current study. The patients were divided into two subgroups according to their insomnia and a history of suicide attempts. The auditory event-related potentials were measured to evaluate LDAEP before beginning antidepressants. RESULTS: The scores of total Beck Depression Inventory (BDI) and BDI item 9 (suicide) were higher in insomnia subgroup than non-insomnia subgroup (respectively, p=0.0033 and p=0.03). However, LDAEP did not differ each other. The subgroup with a history of suicide attempts had a higher score of BDI item 9 than the subgroup without a history of suicide attempts (p=0.00012). There was a tendency for the LDAEP to be higher in the subgroup with a history of suicide attempts (1.39+/-0.94 microV) than the subgroup without a history of suicide attempts (1.05+/-0.75 microV), although the difference was not statistically significant (p=0.078). CONCLUSION: Suicidality was related to insomnia. In addition, there was a tendency for serotonin activity to be lower in the subgroup with a history of suicide attempts. In future, more studies are needed.
