Correlation of seminal plasma zinc alpha-2 glycoprotein with semen quality in obese males.

Ya-nan QI; Jing MA; Rui-yu Han; Jing MA; Shu-song Wang

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Correlation of seminal plasma zinc alpha-2 glycoprotein with semen quality in obese males.

Author: Ya-Nan QI ¹ ; Jing MA ² ; Rui-Yu HAN ² ; Jing MA ² ; Shu-Song WANG ¹
Author Information

1. Graduate School, Hebei Medical University, Shijiazhuang, Hebei 050017, China.
2. Hebei Research Institute of Family Planning Science and Technology / Key Laboratory of the National Commission of Health and Family Planning for Family Planning and Healthy Birth, Shijiazhuang, Hebei 050071, China.
Publication Type:Journal Article
Keywords: obesity; semen quality; zinc alpha-2 glycoprotein; seminal plasma zinc
MeSH: Body Mass Index; Humans; Infertility, Male; etiology; metabolism; Male; Obesity; complications; metabolism; Semen; chemistry; Semen Analysis; Seminal Plasma Proteins; analysis; Sperm Count; Sperm Motility; Spermatozoa; metabolism; Waist Circumference
From: National Journal of Andrology 2018;24(3):216-220
CountryChina
Language:Chinese
Abstract:
ObjectiveTo investigate the relationship between seminal plasma zinc alpha-2 glycoprotein (ZAG) and semen quality in obese males.
METHODSThis study included 130 obese male patients with idiopathic infertility Based on the concentration of seminal plasma ZAG, we divided the patients into three tertile groups: tertile 1 (T1, 73.45－97.15 μg/ml, n = 43), T2 (97.16－115.46 μg/ml, n = 44), and T3 (115.47－220.11 μg/ml, n = 43). We measured the concentrations of seminal plasma zinc (SPZ) and ZAG of the patients by ELISA, obtained the semen parameters, and analyzed the correlation of semen quality with the levels of SPZ and ZAG and the influence of obesity on SPZ, ZAG and semen quality.
RESULTSThe mean level of seminal plasma ZAG in the 130 obese male patients was (111.29 ± 26.50) μg/ml. There were statistically significant differences in sperm concentration and total sperm count among the three tertile groups (P < 0.05). The level of seminal plasma ZAG was correlated negatively with the body mass index (BMI), waist circumference (WC), sperm concentration and sperm count (P < 0.01), that of SPZ positively with BMI and WC (P < 0.05) but negatively with semen volume and the percentage of progressively motile sperm (P < 0.05). The level of serum ZAG, however, exhibited no correlation with SPZ, seminal plasma ZAG or semen quality. Obesity was found to be associated with significantly decreased concentration of seminal plasma ZAG and percentage of progressively motile sperm but remarkably increased level of SPZ (P < 0.05).
CONCLUSIONSObesity may induce the metabolic disorder of SPZ and ZAG, change the microenvironment of seminal plasma, and consequently affect semen quality.