Correlation of 5-hydroxytryptamine transporter gene-linked polymorphic region with lifelong premature ejaculation: Progress in studies.
- Author:
Hao GENG
1
;
Xian-Sheng ZHANG
1
Author Information
1. Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
- Publication Type:Journal Article
- Keywords:
5-hydroxytryptamine transporter;
gene polymorphism;
selective serotonin reuptake inhibitor;
lifelong premature ejaculation
- MeSH:
Adult;
Ejaculation;
Humans;
Male;
Polymorphism, Genetic;
Premature Ejaculation;
genetics;
Serotonin Plasma Membrane Transport Proteins;
genetics
- From:
National Journal of Andrology
2018;24(3):268-271
- CountryChina
- Language:Chinese
-
Abstract:
Premature ejaculation (PE), as one of the most common male sexual dysfunctions, has a serious negative impact on the sexual satisfaction of the patients and their sexual partners. Lifelong PE is a most common type and a current focus of research as well. The etiology and pathogenesis of this disease are not yet clear and genetic factors are considered to be closely related to lifelong PE. Studies show that the 5-hydroxytryptamine transporter (5-HTT) gene plays an important role in the development and progression of lifelong premature ejaculation and the 5-HTT-linked polymorphic region (5-HTTLPR) has attracted much attention in recent years. This article presents an overview on the correlation between 5-HTTLPR and lifelong PE.
