Impact of inhaled anesthetics on the male reproductive system and its mechanisms: An update.
- Author:
Hai-Yan ZHOU
1
;
Xian-Gang MO
2
;
Xiao-Hua ZOU
3
;
Bai-Long HU
3
Author Information
1. Research Center of Clinical Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guzhou 550004, China.
2. General Ward, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guzhou 550004, China.
3. Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guzhou 550004, China.
- Publication Type:Journal Article
- Keywords:
desflurane;
male reproductive system;
reproductive hormones;
sevoflurane;
isoflurane
- MeSH:
Anesthetics, Inhalation;
pharmacology;
Apoptosis;
DNA Damage;
Genitalia, Male;
drug effects;
Humans;
Isoflurane;
pharmacology;
Male;
Occupational Exposure;
Sperm Count;
Sperm Motility;
drug effects;
Spermatozoa;
drug effects
- From:
National Journal of Andrology
2018;24(3):272-276
- CountryChina
- Language:Chinese
-
Abstract:
The safety of occupational exposure to inhaled anesthetics remains a concern among the medical staff in hospitals. Few reports are seen about the impact of inhaled anesthetics on the reproductive system, particularly that of males. Several clinical and basic studies on isoflurane and others suggest that inhaled anesthetics affect the reproductive system of rodents by decreasing the sperm count, inducing sperm morphological abnormality, reducing sperm motility, and changing the levels of reproductive hormones, the underlying mechanisms of which are mainly associated with the alteration of the hypothalamic-pituitary-gonadal axis and DNA damage and apoptosis of reproductive cells. This article reviews the main impacts of inhaled anesthetics on the male reproductive system and the possible mechanisms.
