Finasteride inhibits microvascular density and VEGF expression in the seminal vesicle of rats.

Shuai Sun; Yong-chuan Wang; Kai Guo; Jing DU; Hai-jun Zhou; An-ji Ren

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Finasteride inhibits microvascular density and VEGF expression in the seminal vesicle of rats.

Author: Shuai SUN ¹ ; Yong-Chuan WANG ² ; Kai GUO ¹ ; Jing DU ² ; Hai-Jun ZHOU ² ; An-Ji REN ²
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1. Department of Surgery, Weifang Medical College, Weifang, Shandong 261061, China.
2. Department of Urology, Weifang Hospital of Traditional Chinese Medicine, Weifang, Shandong 261041, China.
Publication Type:Journal Article
Keywords: CD34; finasteride; microvascular density; vascular endothelial growth factor; seminal vesicle
MeSH: Angiogenesis Inhibitors; pharmacology; Animals; Antigens, CD34; metabolism; Finasteride; pharmacology; Immunohistochemistry; Male; Neovascularization, Physiologic; drug effects; Random Allocation; Rats; Rats, Sprague-Dawley; Seminal Vesicles; blood supply; drug effects; metabolism; Vascular Endothelial Growth Factor A; metabolism
From:National Journal of Andrology 2018;24(5):387-392
CountryChina
Language:Chinese
Abstract:
ObjectiveTo investigate the effect of finasteride on the microvascular density (MVD) and the expression of the vascular endothelial growth factor (VEGF) in the seminal vesicle of rats.
METHODSForty male SD rats were randomly and equally divided into groups A, B, C and D, those in groups A and B fed with normal saline as the control and those in C and D with finasteride at 40 mg per kg of the body weight per day, A and C for 14 days and B and D for 28 days. Then the seminal vesicles of the animals were harvested for HE staining, measurement of MVD, determination of the expressions of CD34 and VEGF by immunohistochemistry, and observation of histomorphological changes in the seminal vesicle.
RESULTSThe expressions of CD34 in groups C and D were decreased by 6.7% and 15.8% as compared with those in A and B (P<0.01), and that in group D decreased by 9.3% in comparison with that in C (P<0.01). The expression indexes of VEGF in groups C and D were decreased by 6.9% and 14.1% as compared with those in A and B (P<0.01), and that in group D decreased by 9.0% in comparison with that in C (P<0.01).
CONCLUSIONSFinasteride can inhibit the expression of VEGF in the seminal vesicle tissue of the rat and hence suppress the angiogenesis of microvessels of the seminal vesicle.