Independent external verification of the nomograms for predicting lymph node metastasis in penile cancer.
- Author:
Jing LI
1
;
Bin WANG
1
;
Shun-Sheng ZHENG
1
;
Fang-Jian ZHOU
2
;
Jian-An YANG
1
;
Dao-Zhang YUAN
1
;
Yan-Fei CHEN
1
Author Information
- Publication Type:Journal Article
- Keywords: Bhagat nomogram; Zhu nomogram; lymph node metastasis; prediction; penile cancer
- MeSH: Adult; Aged; Aged, 80 and over; Area Under Curve; Humans; Lymph Node Excision; Lymph Nodes; pathology; Lymphatic Metastasis; Male; Middle Aged; Nomograms; Penile Neoplasms; pathology; ROC Curve; Retrospective Studies
- From:National Journal of Andrology 2018;24(5):399-403
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the two newly established nomograms for predicting lymph node metastasis in penile cancer based on the clinical data on a large cohort of patients.
METHODSWe retrospectively studied the clinical data on 93 patients with penile cancer treated in the Center for Tumor Prevention and Treatment. Using the two recently established nomograms (Bhagat nomogram and Zhu nomogram), we predicted lymph node metastasis in the patients, analyzed the differences between prediction and the results of postoperative pathology, and compared the accuracy of prediction between the two nomograms with the receiver operating characteristic (ROC) curve and the area under the curve (AUC).
RESULTSThe median age of the patients was 55 (27-82) years. Positive lymph nodes were found in 31 cases (33.3%) postoperatively and in 9 (21.9%) of the 41 clinically negative cases. The AUC of the Bhagat nomogram was 0.739 and that of Zhu nomogram was 0.808, both of which were similar to the prediction accuracy of internal verification and manifested a medium predictive ability.
CONCLUSIONSThe newly established Bhagat and Zhu nomograms can be used for predicting lymph node metastasis in penile cancer, but with a low precision, and therefore cannot be relied exclusively for the option of inguinal lymphadenectomy.